guccaggagcag...gacucagacuga
(a) What is the corresponding complementary DNA sequence? [1 mark]
(b) What is the amino-acid sequence of the corresponding gene product (protein)? [2 marks]
(c) If the mRNA sequence were eukaryotic instead of prokaryotic, what could you say about the corresponding gene (DNA sequence) from which it was transcribed? [2 marks]
(a) Briefly outline the thought experiment which is provided to support the hypothesis that the genetic code is arbitrary. (No more than 200 words.) [2 marks]
(b) Briefly outline the major objections to the hypothesis that the genetic code is arbitrary, as discussed in the article itself, including the postscriptum. (No more than 200 words.) [2 marks]
(c) Based on what you've learned so far, can you elaborate the objections from part b, lending them even more credibility? Can you think of additional objections to Hofstadter's hypothesis that are not mentioned in the article? (No more than 200 words.) [3 marks]
A | L | S | A | L | S | ||
---|---|---|---|---|---|---|---|
0 | 0 | 0 | 0 | 0 | 0 | 0 | |
A | 0 | 5 | 0 | 1 | 5 | 0 | 1 |
N | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
A | 0 | 5 | 0 | 2 | 6 | 0 | 2 |
A | 0 | 5 | 3 | 1 | ? | 4 | 1 |
L | 0 | 0 | ? | 2 | 0 | 12 | 4 |
L | 0 | 0 | 5 | 7 | ? | 5 | 9 |
(a) Complete the table, by replacing the "?"'s with the appropriate numbers. [3 marks]
(b) From the table, give the optimal local alignment for these two sequences. [3 marks]
(b) Align the following two alignments of DNA sequences. Use the
scoring matrix in which a match gets a value of +2, a mismatch gets
a value of -1, and a (base,gap) pair gets a value of -4.
A (gap,gap) pair gets a value of 0. [3 marks]
Profile 1:
ACGC
A-GC
Profile 2:
ACCT
ACC-