| Abstract |
The fabrication of nanoscale DNA and RNA structures at surfaces
has become an invaluable biomaterials methodology for both biotechnological
and non-biotechnological applications. Even greater functionality can be
created by both the manipulation of the nucleic acids with surface enzymatic
transformations and the incorporation of nucleic acid-coated gold
nanoparticles into these interfaces. I will describe our recent efforts to
create nanoparticle-enhanced nucleic acid microarray biosensor processes for
the ultrasensitive, multiplexed detection of surface bioaffinity
interactions, with specific applications to genomic DNA detection, SNP
genotyping, micro RNA profiling, and the use of RNA aptamer arrays for
proteomics.
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